Smooth muscle tone in the prostate, mediated by α1A receptors; blocking them leads them leads to relaxation of smooth muscle in the bladder neck and prostate
Silodosin selectively binds to alpha-1A adrenergic receptors
Improves urine flow and decreases symptoms of BPH
Dutasteride a 5-alpha-reductase inhibitor
Treatment with Silodosin significantly improved urinary symptoms and compared with placebo and well tolerate